Internet Archive Scholar

Cord Blood Transplantation from Unrelated Donors in Adults with High-Risk Acute Myeloid Leukemia

Jaime Sanz, Miguel A. Sanz, Silvana Saavedra, Ignacio Lorenzo, Pau Montesinos, Leonor Senent, Dolores Planelles, Luis Larrea, Guillermo Martín, Javier Palau, Isidro Jarque, Jesús Martínez (+7 others)
2010 Biology of Blood and Marrow Transplantation  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (253.4 kB)
https://web.archive.org/web/20130614030604/http://www.hematologialafe.es/DOCUMENTOS_C/INVESTIGACION/PUBLICACIONES/PUBLICACIONES%202010/SAN%20J_CORD%20BLOOD%20TRANSPLANTATION%20FROM%20UNRELATED%20DONORS.PDF

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2013; you can also visit the original URL. The file type is application/pdf.

Clinical studies focused on disease-specific outcomes of cord blood transplant (CBT) from unrelated donors are limited. We analyzed the outcome and prognostic factors of 49 adults with high-risk acute myelogenous leukemia (AML) receiving single-unit CBT from unrelated donors after myeloablative (MA) conditioning at a single institution. Conditioning regimens were based on the combination of thiotepa, busulfan (Bu), cyclophospamide (Cy), or fludarabine (Flu), and antithymocyte globulin (ATG).
more » ... ulative incidence of myeloid and platelet engraftment was 96% and 73% at a median time of 20 and 62 days, respectively. Engraftment was significantly faster for patients receiving higher doses of CD34 1 cells. Confidence Interval of graft-versushost disease (GVHD), acute GVHD (aGVHD) grade II-IV, III-IV, and extensive chronic GVHD (cGVHD) were 26%, 15%, and 30%, respectively. Leukemia-free survival (LFS), nonrelapse mortality (NRM), and relapse at 2 years were 42%, 39%, and 19%, respectively. Low number of total nucleated cells (TNC) had a negative impact on NRM and LFS. Patients transplanted in first complete remission (CR1) receiving TNC above 2 Â 10 7 /kg had a 4-year LFS of 75%. These results show that CBT from unrelated donors is a curative treatment for a substantial number of patients with high-risk AML, particularly if transplant is performed with highly cellular units in patients in first CR. Biol Blood Marrow Transplant 16: 86-94 (
doi:10.1016/j.bbmt.2009.09.001 pmid:19744570 fatcat:dt5zu4oudvcjdof2vthnbkkmz4
Open Access
Citation

Jaime Sanz, Miguel A. Sanz, Silvana Saavedra, Ignacio Lorenzo, Pau Montesinos, Leonor Senent, Dolores Planelles, Luis Larrea, Guillermo Martín, Javier Palau, Isidro Jarque, Jesús Martínez, Javier de la Rubia, Federico Moscardó, Mónica Romero, Irene Luna, Alberto Montava, Sergio Cañabate, Guillermo F. Sanz. "Cord Blood Transplantation from Unrelated Donors in Adults with High-Risk Acute Myeloid Leukemia." Biology of Blood and Marrow Transplantation 16.1 (2010) 86-94