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TheDrosophilainsulin/IGF receptor controls growth and size by modulating PtdInsP3 levels
2002
Development
Understanding the control of size is of fundamental biological and clinical importance. Insulin/IGF signaling during development controls growth and size, possibly by coordinating the activities of the Ras and PI 3-kinase signaling pathways. We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding sites of the PI 3-kinase adaptor p60 completely abrogates Chico function.
doi:10.1242/dev.129.17.4103
fatcat:ft4eydzpu5cnxmtqbb2htfklpq