Marked Continuous-Time Markov Chain Modelling of Burst Behaviour for Single Ion Channels

Frank G. Ball, Robin K. Milne, Geoffrey F. Yeo
2007 Journal of Applied Mathematics and Decision Sciences  
Patch clamp recordings from ion channels often showburstingbehaviour, that is, periods of repetitive activity, which are noticeably separated from each other by periods of inactivity. A number of authors have obtained results for important properties of theoretical and empirical bursts when channel gating is modelled by a continuous-time Markov chain with a finite-state space. We show how the use of marked continuous-time Markov chains can simplify the derivation of (i) the distributions of
more » ... ral burst properties, including the total open time, the total charge transfer, and the number of openings in a burst, and (ii) the form of these distributions when the underlying gating process is time reversible and in equilibrium.
doi:10.1155/2007/48138 fatcat:rtfi3tj7pff5tmipju3ndaxbxe