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MgO Implanted in Rat Tibia Bone Marrow is Osteoinductive through the Formation of a Matrix, Containing Hydroxyapatite

Håkan Nygren, Per Malmberg, Yang Liu
2016 Materials Science Forum  

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Healing of rat tibia after intramedullary implantation of MgO was analysed by Environmental Scanning Electron Microscopy (ESEM) and Energy-Dispersive X-ray spectroscopy (EDX). The results indicated the formation of hydroxyl-apatite (HA) in the entire intramedullary space after 1 week of healing. Then, corroded Mg, MgO and MgCO3 were incubated with DMEM in vitro for 24 h and the surface of the material was analysed by EDX and Time-of-Flight Secondary Ion Mass (ToF-SIMS). The chemical analysis of
more » ... the Mg corrosion products indicate that HA is formed at the material surface and that MgCO3 was an efficient catalyzer of HA formation
doi:10.4028/www.scientific.net/msf.879.1404 fatcat:s5d3cwpuq5cgpahajczcwh47qy
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Håkan Nygren, Per Malmberg, Yang Liu. "MgO Implanted in Rat Tibia Bone Marrow is Osteoinductive through the Formation of a Matrix, Containing Hydroxyapatite." Materials Science Forum (2016) 1404-1407