MgO Implanted in Rat Tibia Bone Marrow is Osteoinductive through the Formation of a Matrix, Containing Hydroxyapatite

Håkan Nygren, Per Malmberg, Yang Liu
2016 Materials Science Forum  
Healing of rat tibia after intramedullary implantation of MgO was analysed by Environmental Scanning Electron Microscopy (ESEM) and Energy-Dispersive X-ray spectroscopy (EDX). The results indicated the formation of hydroxyl-apatite (HA) in the entire intramedullary space after 1 week of healing. Then, corroded Mg, MgO and MgCO3 were incubated with DMEM in vitro for 24 h and the surface of the material was analysed by EDX and Time-of-Flight Secondary Ion Mass (ToF-SIMS). The chemical analysis of
more » ... the Mg corrosion products indicate that HA is formed at the material surface and that MgCO3 was an efficient catalyzer of HA formation
doi:10.4028/ fatcat:s5d3cwpuq5cgpahajczcwh47qy