Effect of Cyclic Guanosine 3′,5′-Monophosphate on the Synthesis of Enzymes Sensitive to Catabolite Repression in Intact Cells of Escherichia coli

Michael Artman, Seymour Werthamer
1974 Journal of Bacteriology  
Cyclic guanosine 3',5'-monophosphate inhibits the synthesis of ,-galactosidase and tryptophanase in cultures of Escherichia coli growing in minimal media with glucose or glycerol as the carbon source. Cyclic guanosine 3',5'-monophosphate acts at the transcriptional level in the lac operon, it exerts its action at the promoter site of the operon, and requires the presence of functional cyclic adenosine 3',5'-monophosphate receptor protein.
doi:10.1128/jb.120.2.980-983.1974 fatcat:rvtnl2pcsngdrho3x7rmvb4yru