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MicroRNA-222 Regulates Melanoma Plasticity
Journal of Clinical Medicine
Melanoma is one of the most aggressive and highly resistant tumors. Cell plasticity in melanoma is one of the main culprits behind its metastatic capabilities. The detailed molecular mechanisms controlling melanoma plasticity are still not completely understood. Here we combine mathematical models of phenotypic switching with experiments on IgR39 human melanoma cells to identify possible key targets to impair phenotypic switching. Our mathematical model shows that a cancer stem celldoi:10.3390/jcm9082573 pmid:32784455 fatcat:vnw7nbcr7fhfrlki23vjdbzsfm