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Trimethylaminuria (fish-odor syndrome) is a rare metabolic disorder characterized by a body malodor similar to that of decaying fish. The condition results from mutations affecting the flavincontaining monooxygenase 3 (FMO3) gene. Affected individuals may exhibit a variety of psychosocial phenomena. A high index of suspicion for this disorder needs to be maintained when treating individuals presenting with a history of real or perceived body odor. Observation: We evaluated a 41-year-old man whodoi:10.1001/archderm.143.1.81 pmid:17224546 fatcat:mq3tfuzq3va2hiiyznvtl5sl7e