Primary Cutaneous Follicle Center Lymphoma (PCFCL) is a big entity of a large group of B cell lymphoma. In this paper, we report a case of (PCFCL) with particular clinical presentation (huge mandibular mass) successfully treated by a surgical approach followed by R-CHOP chemotherapy. The aiming of our article is to highlight the role of surgery in the management of this group of tumors. Our case concerns a 47 years old female patient, admitted for a large red tumor in her right lower cheek. We

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... erformed a surgical resection with 1 cm marges, followed by a reconstruction with a major pectoralis flap. The histopathological and immunohistochemical came back in favor of centrofollicular B cell cutaneous lymphoma. The patient then benefited from 2 cures of R-CHOP chemotherapy followed by 3 cures of R.