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Heparanase Uptake Is Mediated by Cell Membrane Heparan Sulfate Proteoglycans
2004
Journal of Biological Chemistry
Heparanase is a mammalian endoglycosidase that degrades heparan sulfate (HS) at specific intrachain sites, an activity that is strongly implicated in cell dissemination associated with metastasis and inflammation. In addition to its structural role in extracellular matrix assembly and integrity, HS sequesters a multitude of polypeptides that reside in the extracellular matrix as a reservoir. A variety of growth factors, cytokines, chemokines, and enzymes can be released by heparanase activity
doi:10.1074/jbc.m402131200
pmid:15292202
fatcat:a5sgfyz5ivbidowr4qdipku3oq