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Biomimetic materials that replicate biological functions have great promise for use as therapeutics in regenerative medicine applications. Heparan sulfate (HS) is the natural binding partner for growth factors enabling longer half-lives and potentiation of their signaling. In this study a water soluble chitosan-arginine was modified with sulfate moieties in order to mimic the structure of HS. Sulfated chitosan-arginine with a degree of sulfation of 58% bound fibroblast growth factor 2 withdoi:10.1002/adfm.201802818 fatcat:iv5upvffdngvphat7nzvmh4f4m