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Haematuria and Outcomes in Patients with Diabetic Chronic Kidney Disease
2015
Hong Kong Journal of Nephrology
Results: HFHS diet led to vacuolization and thyroidisation of the renal tubules. Glucose caused mitochondrial fragmentation and cellular apoptosis in HK2 cells. Autophagy was activated in glucose-treated cells as evidenced by the enhanced LC3B-II expression and autophagosome formation. When autophagy was inhibited, either by the inhibitor, 3-MA, or by siATG5, tubular cells were more susceptible to glucose-induced mitochondrial fragmentation and cellular apoptosis. When MFN1 or MFN2 was
doi:10.1016/j.hkjn.2015.08.023
fatcat:oeq2aftievc4fpr5pbzfpqwzsq