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Functional polymorphism in human CYP4F2 decreases 20-HETE production
2007
Physiological Genomics
Hydroxyeicosatetraenoic acid (20-HETE) plays an important role in the regulation of renal tubular and vascular function and a deficiency in the renal formation of 20-HETE has been linked to the development of hypertension. The cytochrome P450 4F2 (CYP4F2) gene encodes for the major CYP enzyme responsible for the synthesis of 20-HETE in the human kidney. We screened two human sampling panels (African and European Americans: n ϭ 24 and 23 individuals, respectively) using PCR and DNA resequencing
doi:10.1152/physiolgenomics.00003.2007
pmid:17341693
fatcat:dkrto6yh5feqvd4rai2bd5g7lu