International Journal of Research in Pharmacy and Science Design of Buoyant Famotidine Loaded Microballoons Directed for Upper Small Intestinal Absorption Window

Chouhan Mahendra, Agrawal Gp, Jain Ashish, Patidar Sandeep, Chouhan Mahendra, Chouhan Mahendra
2013 Int. J. Res. Pharm. Sci. 2013 et al. IJRPS   unpublished
The purpose of this study was to evaluate the potential of floating microballoons. Famotidine was chosen as a model drug because of its poor absorption and short half-life in the lower gastrointestinal tract. A solvent diffusion technique was adopted to prepare famotidine loaded microballoons (FMD-microballoons) using Eudragit S 100 and Hyaluronic acid. The effect of various formulations and process variables including drug content, polymer amount, surfactant concentration, stirring speed and
more » ... mperature were investigated in detail. The final formulation attributes of FMD-microballoons viz. 121 ± 3 µm size and 79 ± 5 % drug content. Drug release of FMD-microballoons was studied using paddle type dissolution apparatus demonstrated the burst followed by slow sustained release profile. The buoyancy study revealed that FMD-microballoons had excellent floating ability in simulated biological fluids, while stability study confirmed that 4±1°C temperature was suitable without any detrimental effect on formulation. A radiographical study was conducted in male rabbits after oral administration of barium sulphate loaded microballoons, it was found that microballoons remained buoyant even after 4 h satisfactory for a gastroretentive formulation. Therefore, FMD-microballoons exhibited excellent floatability, high buoyancy and prolonged drug release necessary for oral administration.