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Intrahepatic cholangiocarcinoma (ICC) is highly invasive and has poor prognosis. At present, there is no effective adjuvant treatment. With the indepth researches on ICC-related tumor microenvironment, gene, protein, epigenetic modification and signaling pathway, the potential therapeutic targets have been found. This article will review the novel potential therapeutic targets of ICC.doi:10.3971/j.issn.1000-8578.2021.20.1248 doaj:80fb895dfc274f1698c83af55269ba9d fatcat:ezcv3mezwvelzhbdcvlurhfzry