CONCENTRATION OF SOLUBLE LEPTIN RECEPTOR IN POPULATION

Josef Bartek, David Stejskal, Pavel Stejskal, Ivo Oral
2000 Biomedical Papers of the Faculty of Medicine of Palacky University  
Examinations were performed in 568 probands (217 men, 351 women) selected randomly from healthy population according to the following criterion: no treatment in the last six weeks for any disease. All probands were subjected to determination of BMI, cholesterol, triacylglycerols, LDL-cholesterol, intact proinsulin, insulin, uric acid, ALT, AST, GMT, LD, CRP, aterogenic plasma index, leptin, and soluble leptin receptor. We determined concentration of soluble leptin receptor in population sample
more » ... population sample of 560 probands. A positive correlation between leptinemia and BMI value was confirmed. It was found that Ob-Re concentration did not correlate with common anthropometrical parameters nor leptin concentration in the serum, but correlated negatively only with insulin and plasma aterogenity. This finding indicates an increased presence of free leptin in patients with signs of insulin (therefore also leptin) resistance.
doi:10.5507/bp.2000.012 fatcat:oxfc7j5a3jcpffylomlbhg6oem