Quantitative morphology of the rat kidney during diabetes mellitus and insulin treatment

R. Rasch, J. Dørup
1997 Diabetologia  
Kidney enlargement in streptozotocin (STZ) diabetic rats is well documented [1] [2] [3] [4] . This growth is mainly due to hyperplasia and to a lesser extent to cellular hypertrophy [2, 5] . After insulin treatment and normalization of blood glucose concentration (BGS), kidney weight and glomerular volume decrease [6]. However, little is known about how fast the morphology changes following normalization of BG by insulin treatment and about the morphology of the diabetic kidney after insulin
more » ... atment or fasting. In the present study, quantitative estimation of each tissue component was performed during experimental diabetes and during insulin treatment. The results were compared with the kidney weight response and morphology in fasted diabetic animals and with the kidney weight and morphology in normal animals with hyperglycaemia induced by i. v. glucose injection. Information on kidney morphology in hyperglycaemia and normoglycaemia is a prerequisite to understanding better the physiological abnormalities found in diabetic patients. Abbreviations: CN, Controls; DH10, diabetic, hyperglycaemic for 10 days; DH50, diabetic, hyperglycaemic for 50 days; DH-N2 h, diabetic, hyperglycaemic for 50 days, insulin treated 4 h, normoglycaemic 2 h, DH-N5 d, normoglycaemic 5 days; DH-N15 d, normoglycaemic 15 days; DH-N38 d, normoglycaemic 38 days; DH-F, diabetic, hyperglycaemic for 50 days and fasted 18 h; CN-H10 m, controls, hyperglycaemic 10 min by i. v.
doi:10.1007/s001250050752 pmid:9243101 fatcat:tpvhb6472jfvzixa5ybe65oxfi