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Model-based selection of the robust JAK-STAT activation mechanism
2012
Journal of Theoretical Biology
JAK-STAT pathway family is a principal signaling mechanism in eukaryotic cells. Evolutionary conserved roles of this mechanism include control over fundamental processes such as cell growth or apoptosis. Deregulation of the JAK-STAT signaling is frequently associated with cancerogenesis. JAK-STAT pathways become hyper-activated in many human tumors. Therefore, components of these pathways are an attractive target for drugs, which design requires as adequate models as possible. Although, in
doi:10.1016/j.jtbi.2012.04.031
pmid:22677400
fatcat:zgxnsz5mhzgmnjqvvwvcwqx3wa