Aim: This study compared the cyclic fatigue resistance (CFR) of ROTATE, EdgeTaper Platinum, and K3XF used in an artificial Sshaped canal at an intracanal temperature. Materials and methods A total of 120 files were tested in an artificial S-shaped canal (n=40 each file system). All files placed in experimental setup were rotated in the canal until fracture occurred. For each instrument, the number of cycles to fracture was calculated, and the fractured fragment was measured. The CFR was

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... ed by recording the time to fracture in the canal. The fractured surfaces of the files were scanned at electron microscope to determine the morphologic characteristics of fracture. Data were statistically analyzed (P < 0.05). Results The ROTATE and EdgeTaper Platinum exhibited significantly greater CFR than the K3XF system (P < 0.05). The ROTATE and EdgeTaper Platinum files had similar CFR values (P > 0.05). The fractured fragment lengths were similar among the files (P > 0.05). Conclusions The CFR of the ROTATE and EdgeTaper Platinum in S-shaped canals was found to be higher than that of the K3XF file.