A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase
1995
Biochemistry
Preserved Fulltext
Kanamycin nucleotidyltransferase (KNTase) is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. The enzyme deactivates various antibiotics by transferring a nucleoside monophosphate group from ATP to the 4'-hydroxyl group of the drug. Detailed knowledge of the interactions between the protein and the substrates may lead to the design of aminoglycosides less susceptible to bacterial deactivation. Here we describe the structure of KNTase complexed with
doi:10.1021/bi00041a005
pmid:7577914
fatcat:lea22gxo5ncmzbrhboibzcfk5u