Schistosomiasis is a chronic disease, caused by Schistosoma species, affecting 200 million people worldwide and causing at least 300,000 deaths annually. Currently, no vaccines are available and Praziquantel is the standard anti-schistosomiasis drug. Praziquantel disrupts the tegument of adult worms, but not juvenile parasites and it does I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the policy and procedures of The University of

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... eensland, the thesis be made available for research and study in accordance with the Copyright Act 1968 unless a period of embargo has been approved by the Dean of the Graduate School.