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Enzymatic reactions are key components in the metabolic pathway and have been classified in several ways. We have also developed a classification system for the enzymatic reactions based on chemical transformation mechanisms. Using this classification system, we extracted and annotated conserved sequences of reactions from the KEGG PATHWAY database, successfully defined 33 functionally well explained sequences, and termed them as reaction modules. These modules often correspond to gene clustersdoi:10.2142/biophys.53.s256_6 fatcat:ot7ydlkhrfdsznkvzolh4foxdu