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The concerted activities of kinases and phosphatases modulate the phosphorylation levels of proteins, lipids and carbohydrates in eukaryotic cells. Despite considerable effort, we are still missing a holistic picture representing, at a proteome level, the functional relationships between kinases, phosphatases and their substrates. Here we focus on phosphatases and we review and integrate the available information that helps to place the members of the protein phosphatase superfamilies into thedoi:10.1016/j.febslet.2012.05.008 pmid:22626554 pmcid:PMC3437441 fatcat:tkbbjw37brfbpgfh4e5fbtd3si