Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan

Anna Plachti, Shahrzad Kharabian, Simon B Eickhoff, Somayeh Maleki Balajoo, Felix Hoffstaedter, Deepthi P Varikuti, Christiane Jockwitz, Svenja Caspers, Katrin Amunts, Sarah Genon
<span title="2020-08-27">2020</span> <i title="Oxford University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3yly6om4ynhcta4fdjenhrdk5y" style="color: black;">Brain</a> </i> &nbsp;
The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to
more &raquo; ... the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awaa222">doi:10.1093/brain/awaa222</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32851402">pmid:32851402</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7523701/">pmcid:PMC7523701</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/loaqo5mturag7pbmjkbu3h22ka">fatcat:loaqo5mturag7pbmjkbu3h22ka</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200828124239/https://watermark.silverchair.com/awaa222.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArowggK2BgkqhkiG9w0BBwagggKnMIICowIBADCCApwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOUUXOs0OAlYW6-apAgEQgIICbR1azF_Yq1XbF-AJTWN-ITS01zKLaFJOb-T1bokQ54yv0H79yb5yC9tx-iRwl1XXDH85X29Aie3UpeEKp94dIx4jWCKubQ2Zf2gUXltoouzUMjEfSpVL2fp8NeyGE-6-JOZGfY594Eto36G0zRHezX0VN9Na1S2H5T9QGLFyEkC6-cfMH8i8PiBTnwL9miomqCvHK3m577IMQFmXyZqVOkxkNkzpaNscXSwiLiK6SpHtWvRmDwTjZxsGtaqmY5M7r0bwskT5VFQbgHW595FLzWEFLdc-HSpcxfBErfmNzKm3WUr0ujXCHFlOkNC-RnRtD9RWpgs_nPKg_KqsfA7kKwan3G4TB6V5QjMISZDNZzsPfA3BlxYCVZUhGjiLdvEHpxyfHmuyXV3TLRcoozuOM2PzDzW-uiCAgGOr-LOzymgFrYhDNxgAG6R1jiXt8YcyTpARzMhip1IqM7Ha7eoIAURUqfWToTLf_yu6k7bEeUhgcnWz1kfSNH2aRcdgueJ1wiy2k2P7jMmq3mbmsEaTWAAE8RZspSy_skmp3IXjeXxaYAtKH3KlP_6TyIWsdJXXz4h5TfPrfBuLSY3rTp_dpjH42_KfRs-6JZycho3SGNGbamlpA9rIEkDbAGZU1EQ5gbrl48yssHbaJU-vaVk81BrUixRyssTeilXb5Q9pePTWkOItMLeGVmdMrx2OphPu8uwuOx18MlDK8ZtohtL5IS1UJr71dBdWCf14pmXIiETLkdBrpSbLVlZrlyk0q7AnlUYy3XjcfQFrLqpT3ZdNcxQ9P1VoUrUfx-OyK2qKCrA5xDiIeXWVhvqteaexGg" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/brain/awaa222"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523701" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>