Antidiabetic and Hypolipemic Effects of Total Aqueous Extract of Pseudarthria hookeri Wight & Arn. (Fabaceae) on Hemoglobin Glycation in Alloxan induced Diabetic Rats
Pseudarthria hookeri (Fabaceae) is a plant used in traditional medicine in Ivory Coast to treat diabetes. This study aims to evaluate antidiabetic and hypolipemic effects of total aqueous extract of Pseudarthria hookeri (EAPh) on hemoglobin glycation in diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of alloxan (200 mg/kg body weight) to Wistar rats. The diabetic rats were treated orally with daily doses of extracts (800, 1000 and 1200 mg/kg bw) and
... bw) and glibenclamide (10 mg/kg bw) for 28 days, respectively. Blood samples from control and test group animals were used for dosing biochemical parameters. The results showed that EAPh administered orally at doses of 1000 and 1200 mg/kg bw for 28 days, leads to a significant decrease (P < 0.01) in blood glucose levels of diabetic rats. In addition, a significant decrease in serum total cholesterol and triglycerides levels was observed in diabetic rats treated with EAPh (1200 mg/kg bw) associated with an increase (P<0.01) in serum HDL cholesterol levels after 28 days of treatment. Moreover, after 90 days of treatment, EAPh (1200 mg/kg bw) induced a significant decrease (Hba1c < 7 %) in glycated hemoglobin percentage of diabetic rats. Our present study clearly revealed that EAPh possesses potent antihyperglycemic and hypolipemic effects comparable to those of glibenclamide in diabetic rats. These results justify the use of Pseudarthria hookeri (Fabaceae) in traditional medicine to effectively treat diabetes and lipid disorders associated with this pathology.