Computational Approaches in Detecting Non- Coding RNA

Chunyu Wang, Leyi Wei, Maozu Guo, Quan Zou
2013 Current Genomics  
The important role of non coding RNAs (ncRNAs) in the cell has made their identification a critical issue in the biological research. However, traditional approaches such as PT-PCR and Northern Blot are costly. With recent progress in bioinformatics and computational prediction technology, the discovery of ncRNAs has become realistically possible. This paper aims to introduce major computational approaches in the identification of ncRNAs, including homologous search, de novo prediction and
more » ... g in deep sequencing data. Furthermore, related software tools have been compared and reviewed along with a discussion on future improvements.
doi:10.2174/13892029113149990005 pmid:24396270 pmcid:PMC3861888 fatcat:43icugsl6bd4rc7iglozlmsyje