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The flow in channels of microdevices is usually in the developing regime. Three-dimensional laminar flow characteristics of a nanofluid in microchannel plate fin heat sinks are investigated numerically in this paper. Deionized water and Al2O3–water nanofluid are employed as the cooling fluid in our work. The effects of the Reynolds number (100 < Re < 1000), channel aspect ratio (0 < ε < 1), and nanoparticle volume fraction (0.5% < Φ < 5%) on pressure drop and entropy generation in microchanneldoi:10.3390/e21080739 pmid:33267453 fatcat:6otwb7h3sbhczaydvkczzd3thi