Forty albino male rats were Albino rats, ages were less than twenty weeks and average weight 190±10gm were divided randomly into four equal groups and treated for 90 days as following :First group (C) was given normal saline only as a control group. Second group (T1) was given aldactone (8.8 mg/day). Third group (T2) was given aldactone (17.6 mg/day).And fourth group was given aldactone (35.2 mg/day). In the end of the experiment all animals were sacrificed and blood samples were collected

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... tly from the heart and serum samples were isolated to measure sodium, potassium concentration and to estimate renal function. The results of study regarded the potassium concentration were revealed a significant difference (p≤ 0.05) represented by increase in potassium concentration in T1group compared with C group. Also, there was a significant difference represented by increase in potassium concentration in T2group compared with C group.T3 show significant increase in potassium concentration compared with C group. The results of sodium were revealed no significant difference in sodium concentration in T1group compared with C group. Also, there was a significant difference represented by decrease in sodium concentration in T2 and T3 group compared with C group. The result of renal function test revealed there were no significant difference in the concentration of urea between T1group and C group. Also, there was a significant difference (p≤ 0.05) represented by increase in urea concentration in T2group compared with C group. And there was a significant difference represented by increase in T3 group compared with C groups. The concentration of creatinine increased with consumption of aldactone but with no significant difference. The results of liver function test revealed there was significant difference (p≤0.05) represented by increase in GOT concentration in T1group compared with C group. Also there were significant difference between T1group C group. And there was a significant difference represented by increase in T3 group compared with C groups. The concentration of GPT there were no significant difference between T1group and T2 group. Also, there was significant difference in T2 group compared with C group. And significant difference (p≤0.05) represented by increase in GPT concentration in T3group compared with other groups.