Effect of Nickel Chloride on Primary Antibody Production in the Spleen

Judith A. Graham, Donald E. Gardner, Frederick J. Miller, Mary J. Daniels, David L. Coffin
1975 Environmental Health Perspectives  
Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p < 0.05) was observed between the logarithm of (plaques/106 cells) and the nickel concentration administered. Mice injected with 3.09 ,ug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However,
more » ... mice. However, injection of 9.26-12.34 ug Ni2+/g caused significant immunosuppression (p < 0.05).
doi:10.2307/3428218 fatcat:oomri3on5jennogytp355o4ouq