A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is
The Src-like adaptor proteins (SLAP/SLAP2) bind to CBL E3 ubiquitin ligase to down regulate antigen, cytokine, and tyrosine kinase receptor signaling. In contrast to phospho-tyrosine dependent binding of CBL substrates through its tyrosine kinase binding domain (TKBD), CBL TKBD associates with the C-terminal tail of SLAP2 in a phospho-independent manner. To understand the distinct nature of this interaction, a purification protocol for SLAP2 in complex with CBL TKBD was established and thedoi:10.1101/2020.10.08.331397 fatcat:5w24rahnjveftc6qtigqyhrrqe