Reconstructing the Ottoman plague experience is vital to understanding the larger Afro-Eurasian disease zone during the Second Pandemic. This essay deals with two different aspects of this experience. On the one hand, it discusses the historical and historiographical problems that rendered this epidemiological experience mostly invisible to previous scholars of plague. On the other, it reconstructs the empire's plague ecologies, with particular attention to plague's persistence, focalization,

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... d transmission. Further, it uses this epidemiological experience to offer new insights and complicate some commonly held assumptions about plague history and its relationship to plague science.