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Formal Methods in Computer Aided Design (FMCAD'07)
The relationship between changes in gene expression and physical characteristics associated with Down syndrome is not well understood. Chromosome 21 genes interact with nonchromosome 21 genes to produce Down syndrome characteristics. This indirect influence, however, is difficult to empirically define due to the number, size, and complexity of the involved gene regulatory networks. This work links chromosome 21 genes to non-chromosome 21 genes known to interact in a Down syndrome phenotypedoi:10.1109/fmcad.2007.4402003 fatcat:jvdeudauhjeqxdld7b4us52x6e