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Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats
1993
Journal of Cerebral Blood Flow and Metabolism
Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. In the present study, we exam ined whether systemically administered bFGF could pre vent neuronal damage induced by either EAAs or hypox ia-ischemia in vivo. Neuroprotective effects were exam ined in a neonatal model of hypoxia-ischemia (unilateral ligation of the carotid artery followed by exposure to 8% oxygen for 1.5
doi:10.1038/jcbfm.1993.27
pmid:8436614
fatcat:4xcifid37zgvrl42jkjgmr6bwi