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A bstract Herpes virus entry m ediator (HVEM) is a newly discovered m em ber of the tum or necrosis factor receptor (TNFR) superfam ily that has a role in herpes sim plex virus entry, in T cell activation and in tum or im m unity. W e generated m Ab against HVEM and detected soluble HVEM (SHVEM) in the sera of patients with various autoim mune diseases. HVEM was constitutively expressed on CD4 + and CD8 + T cells, CD19 + B cells, CD14 + m onocytes, neutrophils and dendritic cells. In three-waydoi:10.1038/emm.2003.65 pmid:14749527 fatcat:tuusway4vvhljhec3drsiwq7g4