High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases

Hyo Won Jung, Su Jin La, Ji Young Kim, Suk Kyeung Heo, Ju Yang Kim, Sa Wang, Kack Kyun Kim, Ki Man Lee, Hong Rae Cho, Hyeon Woo Lee, Byungsuk Kwon, Byung Sam Kim (+1 others)
2003 Experimental and Molecular Medicine  
A bstract Herpes virus entry m ediator (HVEM) is a newly discovered m em ber of the tum or necrosis factor receptor (TNFR) superfam ily that has a role in herpes sim plex virus entry, in T cell activation and in tum or im m unity. W e generated m Ab against HVEM and detected soluble HVEM (SHVEM) in the sera of patients with various autoim mune diseases. HVEM was constitutively expressed on CD4 + and CD8 + T cells, CD19 + B cells, CD14 + m onocytes, neutrophils and dendritic cells. In three-way
more » ... ells. In three-way MLR, m Ab 122 and 139 were agonists and m Ab 108 had blocking activity. An ELISA was developed to detect sHVEM in patient sera. sHVEM levels were elevated in sera of patients with allergic asthm a, atopic derm atitis and rheum atoid arthritis. The m Abs discussed here m ay be useful for studies of the role of HVEM in immune responses. Detection of soluble HVEM m ight have diagnostic and prognostic value in certain im m unological disorders.
doi:10.1038/emm.2003.65 pmid:14749527 fatcat:tuusway4vvhljhec3drsiwq7g4