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The Sequence Ontology (SO), a member of the Open Biomedical On-tologies (OBOs) library, was developed with the goals of standardizing the vocabulary and semantics of biological--sequence annotation with the goal of increased interoperability for software developers and users of genomic sequences. Here we present our recent developmen-tal approaches to address three issues of import for the SO: (1) repre-sentation of molecular sequences versus abstract sequences; (2) inte-gration with the ChEBIdblp:conf/icbo/BadaE12 fatcat:73sedbgb7radhozxsfqi7u6nde