case the ingestion of antihistaminic tablets was followed by an attack of rigor, nausea, and malaise. Ultimately after a few attacks of this kind (always following the intake of antihistaminics) his patient met with death. I was fortunate enough to connect similar attacks in my case with the intake of the antihistaminic methapyrilene hydrochloride (" diatrin ") before serious damage was done. To exclude the fallacy of post hoc ergo propter hoc I asked the patient after a couple of weeks to

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... t once more the dose of methapyrilene hydrochloride and again fever of 102°F. (38.9°C.), rigor, vomiting, and general malaise reappeared. Recovery followed after three days.