Epstein-Barr Virus-Associated Leiomyomatous Tumors in Immune Compromised and Immune Suppressed Children: Histopathologic and Ultrastructural Features

J Hicks, J Barrish, S-H Zhu, R Nichols
2003 Microscopy and Microanalysis  
Epstein-Barr virus-associated malignancies are well described and are linked to Burkitt's lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, nasopharyngeal carcinoma and lymphoepithelial carcinoma. Not until the AIDS epidemic affected children did the relationship between immune compromise and EBV-associated leiomyomatous tumors become known. With HIVinfected children, EBV-associated smooth muscle tumors are the second most common neoplasm. More recently, it has been noted that children on
more » ... that children on immunosuppressive medications or with immune compromise are at increased risk for development of EBV-associated leiomyomatous tumors.
doi:10.1017/s1431927603446904 fatcat:2b2eny5tlzaivmuspvh4ritu6m