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Epstein-Barr virus-associated malignancies are well described and are linked to Burkitt's lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, nasopharyngeal carcinoma and lymphoepithelial carcinoma. Not until the AIDS epidemic affected children did the relationship between immune compromise and EBV-associated leiomyomatous tumors become known. With HIVinfected children, EBV-associated smooth muscle tumors are the second most common neoplasm. More recently, it has been noted that children ondoi:10.1017/s1431927603446904 fatcat:2b2eny5tlzaivmuspvh4ritu6m