Participation of the intestinal epithelium and mast cells in local mucosal immune responses in commercial poultry

D. J. Caldwell, H. D. Danforth, B. C. Morris, K. A. Ameiss, A. P. McElroy
2004 Poultry Science  
The intestinal mucosa of commercial poultry is continually subjected to invasion or colonization by a wide array of potentially hostile enteric pathogens. Although, recent investigations have focused on lymphocyte involvement in immune responses in the intestine, lymphocyte-mediated immunity alone will not explain the barrier nature of mucosal membranes associated with rejection of many enteric pathogens upon secondary homologous challenge. Our laboratories have focused on nontraditional
more » ... ntraditional elements of mucosal immunity in poultry to better understand host-pathogen interactions in the intestine. Following classical and novel immunization procedures, we have identified an antigen-specific mechanism of immediate responsiveness of the mucosal epithelium characterized by epithelial chloride secretion. This mechanism, characteristic of intestinal anaphylaxis, is mediated by local immune elements. Similar mecha-(Key words: mucosal immunity, intestinal epithelium, mast cell, antibody titer)
doi:10.1093/ps/83.4.591 pmid:15109056 fatcat:mdxt7sj6tjcfpkqbphdtrhtioy