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The earliest threatenings of this formidable complaint demand attention. It is usually preceded for a day or two, or longer, by languor and peevishness ; frequently by nausea and %'omiting, and a costive state of the bowels. The pulse, in the outset, has been found slow, and beating with irregular intervals ; but it afterwards becomes frequent. The urine, at first, is scanty as well as altered in appearance. The face becomes pale and chuffy. Sometimes, as the disease proceeds, violent headache,doi:10.1056/nejm184210260271201 fatcat:7bkdxzuzrfafvjanmdql6mgkoy