Antiparasitic Chemotherapy: From Genomes to Mechanisms

David Horn, Manoj T. Duraisingh
2014 Annual Review of Pharmacology and Toxicology  
Due to the absence of antiparistic vaccines, and the constant threat of drug resistance, the development of novel antiparasitic chemotherapies remains of major importance for disease control. A better understanding of drug transport (uptake and efflux), metabolism and the identification of drug targets, as well as potential drug resistance mechanisms would facilitate the development of more effective therapies. Here, we focus on malaria and African tyrpanosaomiasis. We review existing drugs and
more » ... drug development, emphasizing high-throughput genomic and genetic approaches, which hold great promise for elucidating anti-parasitic mechanisms. We describe the approaches and technologies that have been influential for each parasite and develop some new ideas for future research directions, including strategies for target deconvolution.
doi:10.1146/annurev-pharmtox-011613-135915 pmid:24050701 pmcid:PMC4381542 fatcat:6h22gi6uzfhjlcr3cisjjrwoa4