Submit Manuscript | http://medcraveonline.com posterior segment FBs is derived from metal fragments. A vegetative FB such as wood may reach inner part of eye but is located usually in the anterior segment [3, 4] . Animal matter such as cilia can be carried along with denser matter to the posterior segment [1,2,5]. Ocular damage caused by intraocular foreign bodies (IOFB) can occur by two mechanisms; (1) penetrating injury with its secondary complications and (2) by the presence of IOFB itself

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... using damage from microbial endophthalmitis, toxicity and other inflammatory reactions [4, 6, 7] . Pathological evaluation of various FB in the eye and adnexa can give us bunch of information about the damages to the structures. Aim: To study pathological significance of ophthalmic FB in a referral tertiary institute of north-east India. Materials and Methods This is a hospital based, retrospective, laboratory study conducted in a tertiary ophthalmic institute of north-east India between 2010 to 2015. Different tissues including eyeball specimens received in ocular pathology laboratory were studied in details. Gross examinations were carried out in the (LEICA S6D) dissection microscope and were documented. Histopathological analysis was carried out with Hematoxylin and Eosin (H&E) stain, other special stains and polarizer were used in (ZEISS) microscope Axioskop 40 and documented in (AxioCamMRc) camera. Specialized stains included Perl's stain for iron body, tissue Grams's stain (GIS) for microorganisms, Grocott's methenamine silver stain (GMS) for fungus, periodic acid schiff stain (PAS) for fungus and basement membrane of different structures, Congo red for amyloid to see ancillary pathologies. Sixteen pathological specimens with various FBs were seen and classified. Further hospital records were reviewed for the clinical profile, and other ancillary investigations to correlate the findings. Abstract Foreign bodies (FB) in eye and adnexa are important in ophthalmology particularly in traumatic cases. Intraocular foreign bodies (IOFB) can cause ocular damage by various mechanisms. Pathology of eye trauma is of immense interest as lot of changes in the eye and adnexa are unique and are different from the pathology of rest of the body. This review was done to study pathological significance of ophthalmic FB in a referral tertiary institute of north-east India. Sixteen pathological specimens with various FBs were recorded. This study has been done for the first time in this part of the country. Endopthalmitisis following IOFB is most likely to occur if the foreign body is vegetative in nature. Work-related injuries and metallic IOFB are more prevalent in developed countries [14] . This important pathological documentation of FBs has been done for the first time in this part of the country and its significance will help us to know various effects of FBs on the ocular tissues.