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A survivin-driven tumour-activatable minicircle system for prostate cancer theranostics
Gene vectors driven by tumour-specific promoters to express reporter genes and therapeutic genes are an emerging approach for improved cancer diagnosis and treatment. Minicircles (MCs) are shortened plasmids stripped of prokaryotic sequences and have potency and safety characteristics that are beneficial for clinical translation. We previously developed survivin-driven, tumour-activatable MCs for cancer detection via a secreted blood reporter assay. Here we present a novel theranostic systemdoi:10.1101/2020.06.25.171645 fatcat:wnow3sihvrhvvkvkiuverbpxz4