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We developed a method to estimate the content of the toxic endotoxin in inactivated Salmonella vaccine in D-galactosaminesensitized mice. Ten-fold serially diluted vaccines were injected intraperitoneally into D-galactosamine-sensitized mice. Lethality in the mice was judged 3 days after the injection. The best result was obtained when C3H/HeN mice were used for the test. Correlation was observed between the endotoxin content measured by Limulus amoebocyte lysate assay and the LD 50 in thedoi:10.1292/jvms.66.1591 pmid:15644614 fatcat:wxz3a5y6yzbvtdrdbrdtvjqxbm