Effect of ascorbic acid on lipoprotein lipase activity

J P Kotzé, M J Matthews, W A de Klerk
1974
Baboons kept on hypovitaminotic C diets, but without clinical signs of scurvy, had significantly higher heart muscle lipoprotein lipase activity than baboons on vitamin C 34 mg/kg body mass/day. When the serum vitamin C levels were above 0,35 mg/100 ml the heart muscle lipoprotein lipase was repressed. Serum vitamin C levels below 0,35 mg/100 ml stimulated lipoprotein lipase to between 2 and 3 times the repressed value. Heart muscle lipoprotein lipase from baboons receiving dietary vitamin C
more » ... inhibited by 0,34 mM vitamin C in vitro, whereas heart muscle lipoprotein lipase from baboons on scorbutogenic diets were stimulated by addition of vitamin C in vitro. S. Afr. Med. l., 48, 511 (1974). The uptake of triglyceride fatty acids from the plasma by extrahepatic tissues is facilitated through hydrolysis of the triglycerides by the enzyme, clearing factor lipase or lipoprotein lipase. Various authors have given evidence that
pmid:4207028 fatcat:ov5e6frgwfcelhgquj6xeq4n5m