The main purpose of this article is to consider the factors of external influence on the security of the two states India and Uzbekistan, two of the leading countries in South and Central Asia, and the prospects for successful practical cooperation between them in combating against threats. In writing this research paper, observation, comparison, analysis, historical and statistical methods of empirical and theoretical methods were used. It also looks at the impact of threats such as terrorism,

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... extremism, drug trafficking and the Afghan problem on both countries and regions. The effectiveness of the work is reflected in the chronological coverage of official meetings, agreements and arrangements between the two countries over the past five years in the field of defense and security.