The diagnosis of tuberculosis is elusive because of its insidious nature and distinct clinical presentations. Isolated hepatic tuberculosis is a rare clinical entity among patients with tuberculosis. A 45 years old man was presented with complaints of upper abdominal pain, nausea and vomiting. Proteinuria induced by amyloidosis secondary to isolated hepatic tuberculosis was detected in routine urinalysis. Hepatic tuberculosis diagnosis was established by positive tuberculosis polymerase chain

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... polymerase chain reaction from the liver tissue. A 27 years old man admitted to our hospital with a 2 months history of upper abdominal pain. The patient diagnosis was portal hypertension due to isolated hepatic tuberculosis. Both patients were followed up for 18 months under anti-tuberculosis treatment. Tuberculosis must be suspected in patients with liver mass in imaging studies and should be considered in the differential diagnoses that live in endemic areas for tuberculosis.