This study aims to pinpoint the most important challenges faced by teachers of students with autism spectrum disorder, during Distance Education, in light of the Corona pandemic, and to reveal the differences in the responses of the sample members according to the variables: (gender, experience, school stage, and workplace). The study sample consisted of ( 269 ) male and female teachers of students with autism spectrum disorder in the Kingdom of Saudi Arabia. The study tool (a questionnaire)

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... prepared by the two researchers, and its validity and reliability were verified, and then it was applied to the sample members. The results indicated that teachers of students with autism spectrum disorder, face challenges of a high degree during Distance Education, in light of the Corona pandemic, and that the most challenges they face are: (challenges related to teaching content), followed by (challenges related to students with autism spectrum disorder and their parents), then (challenges related to technology), while (challenges related to administration) came in the last place, and at a high level as well. The results also indicated that there were no statistically significant differences due to such variables: (gender, experience, school stage, and workplace).