Overview of tRNA Modifications in Chloroplasts

Maxime Fages-Lartaud, Martin Frank Hohmann-Marriott
2022 Microorganisms  
The chloroplast is a promising platform for biotechnological innovation due to its compact translation machinery. Nucleotide modifications within a minimal set of tRNAs modulate codon–anticodon interactions that are crucial for translation efficiency. However, a comprehensive assessment of these modifications does not presently exist in chloroplasts. Here, we synthesize all available information concerning tRNA modifications in the chloroplast and assign translation efficiency for each modified
more » ... anticodon–codon pair. In addition, we perform a bioinformatics analysis that links enzymes to tRNA modifications and aminoacylation in the chloroplast of Chlamydomonas reinhardtii. This work provides the first comprehensive analysis of codon and anticodon interactions of chloroplasts and its implication for translation efficiency.
doi:10.3390/microorganisms10020226 pmid:35208681 pmcid:PMC8877259 fatcat:jnnoe7gc6fhjtkg3xclxoqfzwy