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wise. In the lower limb these little cutaneous sphacelae select the superficial portion of the popliteal space and where the flexion of the knee is most active. This can be avoided by operating rapidly and superficially. MEDICINE. Hydrobromate of Quinine and Valerianate of Caffeine in Malaria.-Ceredo, after an exten¬ sive experience, concludes that hydrobromate of qui¬ nine is preferable to the sulphate for the following reasons : i. It is more active in moderate doses. 2. It acts as a nervousdoi:10.1001/jama.1885.02391230013003a fatcat:vixen2fx6fg7fnljiwgr3aowia