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Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer's Disease
Journal of Neuroscience
Reactivation of the cell cycle, including DNA replication, might play a major role in Alzheimer's disease (AD). A more than diploid DNA content in differentiated neurons might alternatively result from chromosome mis-segregation during mitosis in neuronal progenitor cells. It was our objective to distinguish between these two mechanisms for aneuploidy and to provide evidence for a functional cell cycle in AD. Using slide-based cytometry, chromogenic in situ hybridization, and PCR amplificationdoi:10.1523/jneurosci.0379-07.2007 pmid:17596434 fatcat:4demzxwm2rekvf77gj374vshre