The diagnostic value of the TNI-93: a memory test suitable for both literate and illiterate patients [post]

CENDRINE FOUCARD, Juliette Palisson, Catherine Belin, Chloé Bereaux, Julien Dumurgier, Claire Paquet, Bertrand Degos, Elodie Bouaziz-Amar, Didier Maillet, Marion Houot, Béatrice Garcin
2021 unpublished
Background: A significant proportion of Alzheimer disease (AD) patients are illiterate or poorly educated, and only a few memory tests are adapted for these patients. The TNI-93 is a quick memory test that was designed for all patients regardless of their education level. In the present study we aimed at assessing the diagnostic value of the TNI-93 for the screening and diagnosis of patients with biologically confirmed amyloid status.Method: We included all patients who had a lumbar puncture
more » ... ) for the analysis of AD cerebrospinal fluid (CSF) biomarkers, a full neuropsychological assessment that included the TNI-93 and an anatomical brain imaging (MRI/CT scan) at Avicenne Hospital between January 2009 and November 2019. We compared the TNI-93 scores in A+ patients (patients with amyloid abnormalities) and A- patients according to the A T (N) criteria (NIA-AA 2018). We also compared A+T+ patients to A-T- patients.Results: 108 patients were included with a mean age of 66.9 ± 8.5 years old, and mean education level of 8.9 ± 5.16 years, illiterate patients represented 27% of the population. Patients from the A+ group (N= 80) were significantly more impaired than patients from the A- group (N=28) on immediate recall (A+: 5.9±2.8; A-: 7.4±2.6; p=0.001), free recall (A+: 3.5±2.7; A-: 5.9±2.8; p< 0.001), total recall (A+: 5.7±3.5; A-: 7.8±2.8; p< 0.001) and on number of intrusions during the recall phase (A+: 1±1.8; A-: 0.1±0.3; p=0.002). Similar results were observed in the memory subgroup but not in patients with presentation other than memory complaint (ie language impairment or others presentation such as behavioural and hallucination). Similar results with increased significance were observed when we compared A+T+ patients (N=50) to A-T- patients (N=26). Analyses of the ROC curves revealed that the best scores of the TNI-93 test to discriminate A+ patients from A- were immediate recall (Area under curve (AUC): 0.70), free recall (AUC: 0.74) and total recall (AUC: 0.74).Conclusion: We found that the TNI-93's immediate recall, free and total recall are valuable for the diagnosis of amyloid pathology suggestive of AD.
doi:10.21203/ fatcat:t4wgs7rvp5fqvlgalzaoltxrka